PASSPoRT Participating Faculty

The overarching goal of my research program is to develop a mechanistic understanding of host-pathogen interactions with biological consequences to pathogenesis. These interactions promote host immune suppression and enhance pathogen replication in cell and tissue specific manner, but remain incompletely described. Results from these studies will inform on molecular mechanisms of action during infection as well as insights into potential therapeutic targets and mechanisms of action. We currently use biochemical and biophysical methods to identify and characterize components from hosts and pathogens in order to develop an atomic resolution framework.

Research keywords: Host pathogen interface; viral interactions; pathogenesis

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The Mayo Clinic has published a DNA 20mer (selected in vitro to bind myelin) that apparently leads to remyelinization and recovery in a mouse M.S. model. But it only works as a complex with 4 streptavidins, I.P. 3x per week, and is expected to be immunogenic. I have selected [SELEX] non-immunogenic 95mer nucleic acids that reach the brain from intravenous tail vein injections. These could replace the streptavidins, and were selected to carry a cargo of 45mer. Only 4h timepoint so far. Exciting idea for long lifetime.

Research keywords: multiple sclerosis; aptamers; DNA technology

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My laboratory investigates cellular programs that regulate early hematopoietic cell development. Specifically, we are interested in stem cell self-renewal and B cell differentiation in normal development and malignant transformation. We are particularly interested in how signals activated by double-strand DNA breaks (DSBs) integrate with developmental programs to promote normal differentiation and prevent leukemogenesis.

Research keywords: B cell development; Hematopoietic stem cells; DNA damage

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Brain imaging in aging, Alzheimer’s disease, and related diseases (ADRD) with specific focus of translation of novel PET tracers and MR sequences into human studies, clinical trials, and clinical patient populations.

Research keywords: Alzheimer; MRI; PET

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The Personomics Lab, led by Janine Bijsterbosch, PhD, aims to understand how brain connectivity patterns differ from one person to the next by studying the personalized connectome. Using population datasets such as the UK Biobank, the Personomics Lab adopts cutting edge computational techniques to improve the interpretability and reliability of resting state functional connectivity networks and investigate multimodal brain correlates of mental health disorders such as depression.

Research keywords: neuroimaging; mental health; computational neuroscience

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Genetic and environmental correlates of complex behavior (e.g., psychopathology, substance use) and biology (e.g., brain structure and function, inflammation).

Research keywords: Psychopathology; Genetics; Neuroimaging

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In the Brossier lab, we are interested in identifying which factors increase the rate of tumorigenesis following oncogenic mutation and the molecular basis underlying this effect, with an eye towards using this information for patient risk assessment and to identify new targets for therapeutic intervention. Projects in the lab revolve around two major themes: (1) how neurodevelopmental factors (cell type, age) affect response to oncogenic mutation, and (2) how environmental factors (including maternal diet) modulate the effects of mutation on the cell of origin and tumor penetrance.

Research keywords: maternal obesity; Neurofibromatosis Type 1; pediatric glioma

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We focus on mechanisms of CD8 T cell activation in the central nervous system (CNS), and their implications in neurodegeneration and cancer.
By studying the neurodegenerative disease Amyotrophic Lateral Sclerosis 4 (ALS4), caused by a mutation in the gene SETX, we found that CD8 T cells of likely autoimmune origin are activated in the CNS and blood of patients and mice, and correlate with disease progression and resistance to glioma in mice. We want to explore:
The role of CD8 T cells in the pathogenesis of ALS, in humans and mice;
The role of SETX in T cell activation.

Research keywords: Immunology/T cells; Neurodegeneration; Cancer

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The Chaney lab focuses on the development and evaluation of novel imaging biomarkers to investigate the inflammatory component of neurodegenerative diseases. The goals of this work are to enhance understanding, detection, and treatment of devastating neurological diseases through the development of non-invasive translational molecular imaging strategies. Specifically, we are interested in developing Positron Emission Tomography (PET) tracers targeting the innate immune system and defining the role of peripheral and central nervous system (CNS) immune responses in neurodegeneration (e.g., Alzheimer’s disease and multiple sclerosis) and infection. To achieve this, we employ multidisciplinary research at the interface of neuroscience, radiology, and immunology.

Research keywords: Molecular imaging; Neuroinflammation; Neurodegeneratoin

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My research is focused on health and economic burden of obesity and obesity-related multimorbidity, multiple myeloma prevention and control, surgical treatment for obesity, transplant outcomes, and health disparities.

Research keywords: Obesity; Cancer; Disparities

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The Chen Lab’s research focuses on a unique class of RNA – circular RNA (circRNA), with the aim of uncovering circRNAs’ regulatory and functional roles, as well as their clinical implications. By utilizing innovative multi-omic and high-throughput screening approaches to identify the genomic elements, RNA structures, and protein components that regulate circRNA functions, we strive to advance our understanding of circRNA’s biological significance and disease relevance. Our long-term goal is to develop circRNAs as a novel RNA therapeutic platform, revolutionizing next-generation RNA technology and therapeutics.

Research keywords: RNA; Translation; Stress

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Skin has a remarkable ability to tolerate genetic mutations while remaining clinically cancer-free. This suggests that non-mutational factors may influence the capacity for cells to undergo oncogenic transformation. We conduct studies to understand the interaction between aging, epigenetics, and skin cancer with novel, genetic mouse models of cutaneous squamous cell carcinoma and a robust skin cancer biospecimen bank. We also conduct translational studies to identify melanocyte transition states, and determinants of therapeutic response in metastatic melanoma. We utilize state-of-the art technologies including single-cell RNA-sequencing and epigenomics, as well as mechanism studies via mouse modeling, cell culture, and biochemistry.

Research keywords: Melanoma; Squamous cell carcinoma; premalignancy

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Small-cell lung cancer is recalcitrant cancer and the most aggressive form of lung malignancy. My research is focused on developing new therapies for small cell lung cancer in both preclinical and clinical settings. We are especially interested in identifying predictive biomarkers and drug resistance mechanisms. We use state-of-art genomic and high-throughput drug screenings to identify new targets and novel drug combinations. Our research employes cell lines, animal models, and patient samples.

Research keywords: translational research; preclinical; cancer biology

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Our mission is to develop innovative techniques for improving the lives of patients with brain diseases. Our team is currently working on developing the following techniques: ultrasound-mediated brain drug delivery techniques for the treatment of brain cancer, ultrasound-enabled brain tumor biomarker release techniques for the diagnosis of brain cancer, and ultrasound neuromodulation techniques for understanding brain functions.

Research keywords: Neuroengineering; Brain cancer; Neuroscience

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We aim to uncover the spatiotemporal dynamics of molecular signals, and investigates how these features contribute to sleep, learning, and functions of neuromodulators – chemicals made in the brain with profound effects on cellular physiology and animal behavior. We achieve our research objectives by imaging and manipulating, in live brain slices and freely moving mice, intracellular signals with high spatial resolution and temporal precision. We combine these approaches with molecular, cellular, developmental, biochemical, and electrophysiological approaches. In addition to the biology exploration, we also further our research by developing new molecular tools (biosensors, actuators) as well as engineering new instruments.

Research keywords: neuromodulator; sleep; imaging

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A major focus of our lab is to investigate the molecular pathogenesis of kidney diseases mediated by dysfunction of organelles including endoplasmic reticulum (ER), mitochondria and lysosome (autophagy), to discover ER stress biomarkers, and to develop highly-targeted therapies by employing high-throughput drug screening.

Research keywords: ER; Mitochondria; Autophagy

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Our lab studies the mechanisms regulating platelet and leukocyte activation under thromboinflammatory conditions, including coronary artery disease, vasculitis, ischemic stroke, and sickle cell disease.

Research keywords: thromboinflammation; confocal intravital microscopy; platelet and leukocyte

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I’m a neuroscientist who works on profoundly neurodegenerative inherited diseases that mostly affect children and young adults. These are lysosomal storage disorders, due to failed lysosomal function. My lab works to understand these diseases better. which brain regions and cell types are affected. We then use this information to better target therapies (gene therapy and enzyme replacement) to the places where they can be most effective. This work has taken us from mice to large animal models and from the brain to the bowel.

Research keywords: neurodegeneration; gene therapy; genetics

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The Crewe lab uses transgenic mouse lines, cell culture and biochemistry to understand extracellular vesicle (EV)-mediated signaling during homeostatic and pathologic metabolic regulation. We are focused on understanding this in the context of obesity and type 2 diabetes with a particular emphasis on adipocyte-derived EVs. We are particularly excited about a subpopulation of EVs from adipocytes carry damaged mitochondria which are transferred to other organs.

Research keywords: extracellular vesicles; metabolism; Obesity

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The Cruchaga Lab is dedicated to advancing the understanding of neurodegenerative diseases such as Alzheimer disease, other dementias, and stroke, by generating, analyzing and leveraging multi-tissue multi-omic data from large and well characterized cohorts

Research keywords: multi-omics; machine learning; prediction models

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My lab is investigating novel ways to modulate the tumor immune microenvironment to enhance the efficacy of treatment for brain tumors and to improve on their safety for children. We use genetic and orthotopic tumor models and utilize a wide range of tools including single cell RNAseq, CyTOF, and MR and PET imaging. Our goals are to understand the fundamental mechanisms driven by the tumor microenvironment that impede robust treatment response and to reverse them to ultimately improve outcomes in children with brain tumors.

Research keywords: Pediatric brain tumor; Tumor microenviornment; Cancer immunotherapy

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We are broadly interested in studying enteric virus-host interactions. We investigate the interface of rotavirus and SARS-CoV-2 replication and pathogenesis, host mucosal immune responses, and intestinal epithelial cell biology.

Research keywords: enteric viruses; mucosal immunity; virus-host interactions

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Our diverse and interdisciplinary Brain Light Laboratory develops and applies optical methods called high-density diffuse optical tomography for assessing human brain health and function. We develop next generation advancements in hardware and algorithms to obtain higher reliability and image quality. We are currently focused on applications in childhood development, including measuring brain function concurrently with natural behavior in autistic and neurotypical children, as well as point-of-care bedside assessment of brain health in acute care settings in children with congenital heart disease. We also develop and disseminate computational tools for modeling, processing, and analyses of optical data.

Research keywords: optical; neuroscience; human

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Dr. Fitzsimmons-Craft has established programmatic lines of research centering on the use of technology for eating disorder prevention and treatment, eating disorder screening, sociocultural etiological and maintenance factors for eating disorders, eating disorder recovery, and college mental health. Ultimately Dr. Fitzsimmons-Craft’s work aims to disseminate evidence-based interventions from research to practice as well as extend treatments in ways that will reach the large number of people in need of care for mental health problems but who are not receiving services.

Research keywords: digital mental health; public health; eating disorders

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The overarching theme of our research is to understand how brain circuits parse incoming visual information into meaningful collections of objects. This is critical to interact with the world around us.
To study this question, we use behavioral, electrophysiological, optical and viral targeting approaches in non-human primates.

Research keywords: vision; electrophysiology; non-human primates

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Historically, reactive astrocytes and neuroinflammation were thought to arise secondary to neuronal cell death in neurodegenerative diseases with little relevance. However, astrocytes and neuroinflammation are beginning to emerge as critical targets of neurological disorders once thought to afflict neurons selectively. We aim to understand the molecular mechanisms that regulate reactive astrocytes and their neurotoxicity in neurodegenerative diseases, including Alzheimer’s disease. To investigate these mechanisms, we combine biochemistry, molecular biology, cellular models of inflammation and mouse models of neurodegenerative diseases. We are also interested in developing novel therapies targeting these pathways to reduce neuroinflammation for potential therapeutic intervention.

Research keywords: astrocytes; immunotherapies; Alzheimer’s disease

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Quantitative proteomics for understanding protein and proteome modifications.

Research keywords: Mass Spectrometry

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The Gastounioti Lab, also known as the Breast Image Computing Lab, conducts translational breast imaging research towards prediction, early diagnosis, prognosis and response to treatment for breast cancer. Our vision is to foster a vibrant and intellectually stimulating research environment by combining elements of computational breast image analysis, artificial intelligence, and informatics to build technologies with a potential for clinical impact in advancing breast cancer screening and prevention strategies.

Research keywords: computational imaging; artificial intelligence; breast cancer screening

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Dr. Gomez is an Assistant Professor in The Department of Medicine –Division of Oncology at Washington University School of Medicine. The Gomez lab is broadly focused on cancer genomics and bioinformatic analyses. Currently, Dr. Gomez is leading a deep sequencing analysis of Hodgkin lymphoma genomes with the goal of describing somatic events characteristic of this malignancy. This work is currently being broadened toward the investigation of Hodgkin lymphoma genomes using single cell sequencing technology. Dr. Gomez collaborates with members of the Griffith and Fehniger laboratories on projects related to the genomics of Hodgkin and Non-Hodgkin lymphomas. Dr. Gomez’s research goals include developing strategies to translate genomic data into improved patient care. She is specifically interested in working toward the inclusion of diverse human populations in translational genomic research

Research keywords: genomics; cancer; informatics

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Atmospheric chemistry and composition are central drivers of climate change, air quality, and biogeochemical cycling. The GEOS-Chem global 3-D model of atmospheric composition is an essential tool in advancing this understanding. As an open-source model, it is used by hundreds of research groups worldwide and boasts an active community of developers committed to its continuous improvements. This project targets improvements to the computational efficiency of the GEOS-Chem software with a focus on large-scale, parallel instantiations that leverage the massive compute resources now readily available from the cloud. The work requires a solid understanding of algorithms and large-scale software systems.

Research keywords: cloud computing; software systems; atmoshperic simulatioon

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The Gutmann laboratory aims to discover the genomic, genetic, cellular and molecular determinants that cause brain dysfunction by leveraging novel genetically engineered mice, human induced pluripotent stem cells, bioinformatic approaches, and multi-omic analysis methodologies. We use the neurogenetic syndrome, neurofibromatosis type 1 (NF1), in which affected people develop brain and nerve tumors, as well as attention deficit and autism. Specifically, we study (1) the cellular origins of tumors, (2) immune regulation of cancer, (3) the impact of germline genetics on disease heterogeneity, (4) neuronal control of tumor biology, and (5) the mechanisms underlying cell type-specific, brain region-distinct signaling pathway diversity.

Research keywords: cancer neuroscience; cancer immunology; cancer modeling

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We primarily pursue solid-state NMR studies of materials, such as “optically-pumped NMR” of semiconductors (a form of quantum sensing), computation of NMR tensors and predictions of spectra, and research on materials for CO2 capture and sequestration, as well as for hydrogen energy storage and fuels. Much of the work we do is on less-commonly studied NMR species.

Research keywords: Solid-state NMR; Quantum sensing; Materials science

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My group works in theoretical quantum chemistry, with a focus on strongly correlated static electronic structure theory and open quantum system dynamics. We develop methods and algorithms utilizing classical and current noisy-intermediate scale quantum computers.

Research keywords: Theoretical chemistry; Quantum computing; Open quantum systems

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Daily rhythms in molecules, cells, and circuits

Research keywords: cancer neuroscience; glial biology; circadian rhythms

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My overarching research goals involve utilization of genomic information from sarcomas to better understand the pathogenesis of these rare tumors and to identify biomarkers to aid in early cancer detection and therapeutic targets for these aggressive cancers.

Research keywords: sarcoma; cancer biology; cancer predisposition

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The cellular antenna primary cilium is a beautiful and enigmatic structure that underlies some of the most important human diseases. We study primary cilia in the setting of pancreatic islet function and diabetes, using genetic models, metabolic tests, and molecular and cellular imaging to dissect the role of cilia in cellular communication.

Research keywords: Pancreatic islets; Primary cilia; Cell crosstalk

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The lab focuses on interactions of pathogenic Gram-negative bacteria with their hosts, using urinary tract infection (UTI) as our primary model. We also investigate modulation of host immune responses by uropathogenic bacteria, and the influence of sex on UTI pathogenesis. For example, we have used new mouse models of UTI to identify the first kidney epithelial receptor for type 1 pili of uropathogenic E. coli (UPEC), and to define how androgen receptor signaling drives increased severity of UTI. These molecular and cellular mechanisms are now being investigated with flow cytometry, snRNAseq, CRISPR and other techniques.

Research keywords: Bacterial pathogenesis; Immunology; Urinary tract infections

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The research interests in the lab are focused on understanding the role of RNA species (mRNA, sRNA, and circRNAs) in the development, progression, and diagnostic of neurodegenerative diseases. Currently, we am leading research into the prediction of pre-symptomatic Alzheimer’s and Parkinson’s disease using plasma high-throughput RNAseq data in combination with Machine Learning techniques

Research keywords: Neurodegeneration; Transcriptomics; Machine Learning

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My lab investigates the effects of human aging on emotional processes, using a range of in-lab and in-life/ambulatory/at-home measures, such as eye tracking, psychophysiology and experience sampling.

Research keywords: Aging; Emotion; Attention

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SIngle cell and spatial omics for understanding kidney organization across lifespan in health and disease

Research keywords: kidney; single cell and spatial; 2D, 3D imaging

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Our T32 postdoc program is focused on transdisciplinary cancer prevention and control research. Faculty study health equity, disparities, engagement, and the full continuum from prevention through survivorship. Our program includes postdocs from diverse backgrounds and a range of disciplines including, but not limited to, epidemiology, psychology, community health, public health, social work, implementation science, and other related fields. My own research is focused on improve equity and outcomes in cancer screening and early detection, using community engaged research in low resource settings.

Research keywords: cancer control; cancer prevention; health equity

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The Janowski lab focuses on the characterization of novel viruses in order to understand the mechanisms by which they cause disease in humans. We are currently studying the role of astrovirus VA1 in causing encephalitis and other diseases in humans. We are utilizing a brain organoid model, murine model, and a reverse genetics system to comprehensively dissect the mechanisms of astrovirus infection.

Research keywords: Virology; Viral pathogenesis; Neuroinflammation

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Abhinav K. Jha’s research is in the design, evaluation and translation of computational medical imaging methods for optimized performance in diagnostic and therapeutic tasks using quantitative measures of task performance. For this purpose, his group develops novel physics and artificial intelligence (AI)-based methods for image reconstruction, image enhancement, image analysis and task-based image-quality evaluation. One major research direction is in integrating AI and task-based assessment to make medical imaging more comfortable and accessible for patients by reducing acquisition dose and scanning times, and more valuable for physicians by automating image-analysis procedures and providing imaging biomarkers to monitor disease response. This research direction also includes studying the clinical deployment and ethical aspects of AI algorithms. Another major direction of research is developing low-count quantitative imaging methods for personalizing emerging cancer treatments. Towards this goal, his group develops statistical signal-processing approaches that maximize the extracted task-specific information from data measured by imaging systems.

Research keywords: Computational medical imaging; Artificial intelligence; Imaging Science

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The Kefalogianni lab studies the cellular and molecular mechanism of tissue injury and disease progression. Various pathologies are associated with tissue injury, including hypoxia, diabetes, infections, and autoimmune diseases. While mechanisms to repair the damaged tissues get activated, severe or repeated injury can drive non-resolving inflammation, tissue scarring (fibrosis), and progression to chronic disease conditions that may lead to organ function loss. Systemic effects, such as remote organ injuries are also common. Our current projects focus on the roles of cytokines and their cellular and soluble receptors in the progression of rheumatic and kidney diseases.

Research keywords: cell signaling; TNF; fibrosis

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The Kendall Lab studies B lymphocyte contributions to autoimmune and allergic diseases including Type 1 diabetes, rheumatoid arthritis and food allergy. We discovered that B lymphocyte signaling through Bruton’s tyrosine kinase (BTK) governs development of autoreactive cells. Targeting BTK eliminates autoreactive, but not normal cells, making it an attractive therapeutic option for fighting autoimmune disease without causing immunodeficency. We also work with nanoparticle therapeutics. Finally, we have discovered that B lymphocyte signaling is important for proper IgA development, leading to extensive studies of mucosal immunity including gut health, IgA sequences and specificity, and microbiome in relationship to autoimmune disease.

Research keywords: B lymphocytes; Autoimmune disease; Microbiome

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We investigate the mechanisms of non-alcoholic fatty liver disease (NAFLD) with a focus on mitochondria and autophagy. We also seek to develop new therapeutic strategies to reduce hepatic injury after liver resection and transplant of fatty livers. Our study models include mice, rats, and human livers. Our study has potentials to 1) develop therapeutic strategies to reduce fatty liver disease and 2) expand donor liver pool. Currently, fatty donor livers are discarded without transplant.

Research keywords: liver; mitochondria; autophagy

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Our goal is to develop more effective immunotherapies for acute myeloid leukemia (AML). We work at the interface of hematopoietic stem and progenitor cells (HSPCs) and T cells, as AML is a malignancy derived from HSPCs and still harbors many characteristics of its normal counterparts. We use chimeric antigen receptor (CAR) T cell therapy, in which T cells are genetically engineered to attack cancer, as this has achieved success in a variety of hematologic malignancies, such as B-cell lymphoma, multiple myeloma, and acute lymphoblastic leukemia. We aim to extrapolate the success of CAR T cell therapy to AML.

Research keywords: CAR T cells; Hematopoietic stem cells; Cell and gene therapy

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Our research focuses on the mechanisms of synaptic transmission. We utilize cutting-edge multi-color super-resolution imaging tools to examine synaptic function and dysfunction in the brain at molecular, cellular and circuit levels. Our major current directions are to understand how neurotransmitter release is organized and regulated in individual central synapses, and to link dysregulation in synaptic and cellular processes with the circuit and ultimately behavioral impairments observed in autism and Fragile X syndrome. We have recently expanded our interests towards elucidating the role of glia in modulating synaptic function and plasticity.

Research keywords: synaptic transmission; super-resolution microscopy; glia

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The Kornfeld lab pursues two research areas: animal aging and the biology of zinc. Our goals in aging research are to characterize how animals change as they age and identify genetic and pharmacological approaches to extend the health span. We are particularly interested female reproductive aging. Our goals in zinc research are to understand mechanisms of homeostasis in response to both excess and deficiency. We have identified the lysosome as the key storage depot for zinc, and are using state of the art microscopy to define how this organelle is remodeled during zinc homeostasis.

Research keywords: aging; zinc homeostasis; C. elegans

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The overarching goal of our research program is to determine how epithelial cell-derived proteins can be harnessed to mitigate the risk of acute lung injury in various settings, to ultimately reduce the burden of end-stage lung disease. A major focus of our work involves distinguishing the role of locally-derived complement proteins in the lung from those present in the blood, and how they modulate the development of pneumonia and acute lung injury. We use multiple in vitro and in vivo approaches to dissect the mechanism by which these proteins contribute to cellular survival. Additionally, we draw upon a robust biorepository of lung tissue, bronchoalveolar lavage fluid and DNA from human subjects to guide and validate our research.

We have active projects investigating lung injury due to pneumonia, and the short- and long-term consequences of ischemia-reperfusion injury occurring in the context of lung transplantation, with the ultimate goal of mitigating the morbidity and mortality occurring due to these forms of lung injury. Postdocs have the opportunity to develop an expertise in immunology, cell biology, bioinformatics, literature review, and scientific writing as they will address these questions.

Research keywords: Lung; Pneumonia; Transplantation

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1) Our lab studies the connection between plasticity-dependent mechanisms for stroke recovery and sleep-dependent plasticity. Our goal is to develop new, innovative sleep-focused treatments and interventions to improve outcomes in patients with neurological disease.
2) Our lab studies the neuroprotective effect of torpor (a hypothermic and hypometabolic state.

Research keywords: sleep; torpor; neuroprotection

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Our research is aimed at developing effective and efficient, individualized rehabilitation for people with neurological or neurodevelopmental conditions. Our primary interest is human movement and how movement can be a marker of pending conditions (e.g. during development) or be restored after nervous system injury (e.g. stroke). A key tool for our lab is the use of wearable sensors (accelerometers) to quantifying human movement in daily life. This tool offers a convenient, accurate, and economical way of measuring real-world movement outside the clinic or laboratory.

Research keywords: stroke rehabilitation; movement; wearable sensors

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The Leung Lab is focused on developing a mechanistic understanding of host-pathogen interactions that contribute to viral pathogenesis through immune evasion, replication, and spread. We use a multidisciplinary approach to characterize select non-segmented negative sense RNA viruses, including respiratory syncytial virus and Ebola virus, to identify critical targets that can be used as a basis to develop therapeutics or vaccine candidates.

Research keywords: Host Pathogen interactions; Immune Evasion; Viral Pathogenesis

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The Lew Lab builds advanced imaging systems to study biological and chemical systems at the nanoscale. Our technology leverages innovations in applied optics, signal and image processing, design optimization, and physical chemistry. Super-resolution is a key feature of many of our imaging systems–the ability to overcome the resolution limit of wave physics, called the diffraction limit, in order to visualize the nanoscale world. Single-molecule imaging is also a central theme of our research–enabling our technology to see individual molecules as they drive biological and chemical dynamics at the nanoscale.

Research keywords: super-resolution microscopy; single-molecule spectroscopy; nanoscale sensing

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Liu group aims to dissect the neuronal populations and circuits that drive allergic and infectious symptoms, including itchy watery eyes, excessive sneezing, rhinorrhea, and coughing.

Research keywords: Allergy; Viral respiratory infections; neural circuits

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The lab theme is to determine how tyrosine kinases, phosphatases, demethylases and nuclear receptors regulates epigenetic processes that affect cellular homeostasis, immune impairment and cancer cell survival.
Current Projects in Lab
Epigenetic signaling in dampening immune response to tumors
Characterization of new subsets of T cells and neutrophils
Androgen regulated immune response
Characterization of KDM6 inhibitors
New `dual’ therapeutic molecules
Major findings of our lab include:
Discovered 5 new epigenetic events:
Identified a novel lncRNA, NXTAR
Developed inhibitor for ACK1, (R)-9b
Identified AKT Tyr176-phosphorylation
Identified AR Lys609-acetylation
Identified a new class of KDM6 inhibitor

Research keywords: Breast & Prostate Cancer; Immune regulation; Epigenetics

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The Maher lab is an integrated team of experimental and computational biologists focused on translating genome-based discoveries into the clinic. Our research focuses on understanding the molecular mechanisms driving metastatic progression and treatment resistance in cancer. To accomplish this, our lab combines the analysis of large-scale ‘-omics’ data with molecular biology, cellular biology, and biochemistry.

Research keywords: Bioinformatics; Cancer genomics; Noncoding RNAs

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We use mass spectrometry-based proteomics to study signal transduction in disease, with a focus on the NRF2 pathway and ‘dark’ kinases. Ongoing projects include the cryoEM structure of KEAP1/NRF2, cell biology of KEAP1 mutations and biomolecular condensates, and small molecule screens for NRF2 inhibitors, including novel compounds that block one-carbon metabolism. We also study NRF2 in new mouse models of cancer and across clinical tumor biopsies using targeted proteomics. We lead a new clinical trial for a NRF2 inhibitor in head and neck cancer. Understudied kinases are being illuminated through large scale promiscuous biotin proximity proteomics and computational scoring.

Research keywords: proteomics; cancer; signal transduction

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Work in our lab focuses on immune regulation of graft-versus-host disease (GVHD), a debilitating and potentially fatal complication of hematopoietic stem cell transplantation (HSCT). HSCT can cure high-risk malignancies and other blood and bone marrow diseases, yet success is limited by this devastating complication.
We aim to elucidate the biological mechanisms underlying immune tolerance in HSCT and develop approaches to enhance regulatory immune cells for GVHD prevention and treatment. Our goal is to develop a cellular therapy for GVHD with a bench-to-bedside approach, engineering viable advances for prevention and cure, and making HSCT a safer way to cure hematologic diseases.

Research keywords: T cells; cellular therapy; immune regulation

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The McCoy Laboratory studies how microbes navigate nutritional immunity to live on human skin. Our projects commonly employ microbiome, microbiology, immunology, biochemistry, and structural biology techniques to investigate these interactions. Many of our studies revolve focus on the skin commensal Cutibacterium acnes, which is associated with acne vulgaris and can cause infections of indwelling medical devices (e.g., joint replacements). We believe that our investigations will lead to a better understanding of human-microbe interactions and improved diagnostics/therapeutics for patients.

Research keywords: Microbe; Skin; Structure

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The Meers Lab studies how transcription factors interact with and overcome barriers presented by chromatin landscapes to specify developmental and cellular reprogramming outcomes. To do so, we develop cutting-edge epigenomics techniques to map transcription factor binding and chromatin structure in the same context at ultra-high resolution and in single cells. We then marshal our advanced technological approaches and the fundamental molecular insights we uncover to study how transcription factor-chromatin interactions go awry and contribute to pathogenesis in diseases such as cancer. These three areas, Biology, Technology, and Disease, drive a cycle of discovery that fuels our research.

Research keywords: Chromatin; Genomics; Single cell

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We are interested in the cellular, molecular, and functional basis of therapeutic benefit for novel classess of neuropsychiatric drugs. By exploring neuropharmacological impact at various levels of analysis, we come to deeper understanding of normal and dysfunctional signaling in the CNS. We use a combination of in vitro and in vivo rodent models along with imaging, electrophysiology, and molecular techniqes.

Research keywords: neurophysiology; neuropharmacology; neurotransmitters

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The mission of TRIADS is to support transdisciplinary research programs that harness advanced methods and tools in the service of better understanding our world and addressing urgent social issues. We are looking for fellows who are interested in researching critical issues facing society in a collaborative way, including both methodological and applied researchers. We take a broad view of data science and encourage applicants from all research traditions to apply.

Research keywords: Data science; Social science; Interdisciplinary

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The Mudd lab explores the T cell response to viral respiratory pathogens in living human subjects focusing on difficult to sample tissue compartments such as the draining lymph node, the lung mucosa and the nasopharyngeal mucosa. Using cutting edge tools such as single-cell RNA sequencing, paired V(D)J sequencing, TCR cloning and ex vivo human T cell line characterization, we explore the antigen-specific T cell response to these pathogens in our unique human cohorts following vaccination or natural infection.

Research keywords: T cell immunology; human immunology; influenza

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The Muegge Lab is interested in the genetic and metabolic regulation of cell fate decisions. We are especially focused on defining how epithelial stem cells in the gut give rise to the diverse intestinal endocrine system, with the goal of discovering novel ways to treat metabolic diseases using gut hormones. We use cutting edge bulk and single-cell RNA-seq and epigenetic methods. Our work is at the interface of computational genomics, developmental biology, and cellular models of disease. We invite applications from enthusiastic scientists of any disciplinary background interested in joining our collaborative team.

Research keywords: Stem cells; Genomics; Endocrinology

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We aim to uncover the design principles governing the organization of the eukaryotic cell using a combination of quantitative microscopy, single cell transcriptomics, metabolomics, and mathematical modeling.

Research keywords: quantitative cell biology; biophysics; organelles

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Research in my laboratory is focused on the biology of ion channels.
We develop, introduce and use a wide range of molecular biological and biophysical approaches, as well as in vivo gene manipulation to address questions in proteins, cells and animals, and now in humans. These efforts are leading us to detailed understanding of both molecular mechanisms of channel activity, and roles of ion channels in multiple disease processes including diabetes, heart failure, pulmonary disease and epilepsy.

Research keywords: Ion channels; Excitability; Disease

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The Ornitz lab uses molecular, genetic, and biochemical approaches to study the regulation of cell growth, development, homeostasis, and response to injury, in the mouse. Current studies examine Fibroblast Growth Factors, FGF receptors, and a variety of other interacting signaling pathways in neonatal and adult mice, with a focus on skeletal, cardiovascular, and pulmonary development, physiology and injury response. The Ornitz laboratory has constructed FGF and FGF receptor mutants with defects in these and other organ systems. Mutant mice are being studied as genetic and developmental model systems for mesodermal and epithelial patterning, organogenesis, tissue homeostasis, and tissue repair.

Research keywords: mouse molecular genetics; bone homeostasis; alveologenesis

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Cytokine Storm Syndrome (CSS) is a condition of severe, potentially fatal, inflammation. We use a combination of hypothesis-driven and discovery-based approaches, in vitro and in vivo, to determine host factors that regulate CSS from sterile and infectious causes. We focus on the role of autophagy, cell death, and immunometabolism in macrophages and interacting cells. We leverage mouse models and mouse genetics to define the physiological role of these factors and determine their mechanism of action.

Research keywords: autophagy; macrophages; cytokine storm syndrome

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We study regeneration of reproductive cells in segmented worms using single cell RNAseq, transgenics, and live imaging. We also have projects in the lab that focus on cell fate decisions in the embryos via asymmetric cell division, and microbiome-host interactions in the context of regeneration.

Research keywords: regeneration; evo-devo; germline

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My lab focuses broadly on the leukocyte migration (or trafficking) in the setting of tumor immunology. We have been working on a novel leukocyte chemoattractant protein, chemerin. Our ongoing work will continue to further define the by which chemerin mediates its anti-tumor effect, and ultimately we hope to translate this into a first in class immunotherapeutic that could augment leukocyte trafficking to sites of tumor in humans. We have recently received a patent for our tumor targeted immunotherapy and are translating this into the clinic and will work on the first in human clinical trial. As a Physician-Scientist who sees and treats patients with genitourinary malignancies, I have been able to establish a robust human tissue bank and thus another focus in the lab is on translational studies of human prostate cancer tissues using advances multi-omic methods such as single cell RNAseq and multiplexed imaging modalities.

Research keywords: tumor immunology; prostate cancer; leukocyte trafficking

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Our research interests are focused on mechanisms of inflammation from systemic inflammatory disorders. The major focus in the lab is investigating the pathogenic role of CD8 T cells in HLA-B27+ anterior uveitis and ankylosing spondylitis, inflammatory diseases of the eye and spine, respectively.

Research keywords: CD8 T cell; autoimmunity; human immunology

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Our lab uses biomolecules to deliver imaging or cytotoxic cargo, multimodal imaging to monitor the binding of molecular-targeted compounds, acute and temporal pharmacologic approaches to modulate tumor biology, and basic tumor biology combined with preclinical knowledge to improve cancer diagnosis and treatment.

Research keywords: Cancer; Antibody; Imaging

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Dr. Pradhan is the Director for the Center of Clinical Pharmacology at Washington University School of Medicine and the University of Health Sciences and Pharmacy in St. Louis. Her lab investigates novel therapies for migraine, and she identified the delta opioid receptor as a promising target for this disorder. Ongoing studies in her lab are focused on the differential role of mu and delta opioid receptors in headache. Additionally, the lab focuses on identifying the molecular mechanisms that contribute to migraine chronicity, as well as overlapping mechanisms between migraine and neuropsychiatric conditions.

Research keywords: opioids; headache; pain

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Our multidisciplinary team has recently launched two large-scale pragmatic cluster randomized controlled trials to evaluate the effect of multilevel interventions on increasing the uptake of lung cancer screening and tobacco treatment in primary care by providing personalized genomic risks, recommendations, and decision supports to guide healthcare discussions and decision making between patients and clinicians. These projects leveraging both genomic medicine and implementation science in primary care settings will welcome collaborations from trainees pursuing expertise in research trials within real-world settings, particularly those involving smoking and smoking-related diseases, precision medicine, health risk communication, behavior change, and implementation science.

Research keywords: genetics and genomics; smoking cessation; implementation science

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The Ratner Lab is seeking a postdoctoral researcher to work on human T-cell leukemia virus and adult T cell leukemia lymphoma (HTLV). Projects involved molecular and cellular biology and virology, immunology, informatics research including lab bench and biosafety laboratory tissue culture, using state-of-art techniques including humanized mice, single cell RNAseq, CRISPR screens, CUT&RUN sequencing. The projects focus on epigenetic regulation of HTLV, T-cell receptor signaling, viral and cellular protein interactions studies, and functional analyses. We incorporate discoveries into clinical trials, and use human samples as well for these studies.

Research keywords: HTLV; Leukemia; T-cell receptor

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The Rentschler lab studies cardiac physiology and the regulation of gene expression. In recent groundbreaking research, she and others at WashU discovered that cardiac radiotherapy can activate, in part, Notch signaling and reprogram cardiac conduction, which could lead the way to new, less invasive treatments for arrhythmias.

Research keywords: arrhythmias; epigenetics; engineering

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Our laboratory investigates the development of the cerebral cortex and the formation of commissural connections between the two hemispheres of the brain, in particular the development of the corpus callosum. We work with people that have corpus callosum dysgenesis to understand the genetic and developmental causes of these disorders and how they affect cognitive outcome. We also study mouse models of corpus callosum dysgenesis and are studying how brain activity first emerges in the cerebral cortex of a small marsupial called a fat-tailed dunnart. We study mechanisms that regulate brain wiring and how these underpin behavior and cognition.

Research keywords: cerebral cortex; brain development; developmental disorders

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Our lab studies Klebsiella pneumoniae infections and host response with the goal of informing vaccine development. We use a variety of murine models and immunologic assays to study the interplay between bacteria and host. We collaborate with both academia and industry to test cutting-edge vaccine technology and potential therapeutics. We are seeking postdoctoral candidates with experience in bacteriology, immunology, or bioinformatics.

Research keywords: Klebsiella virulence; Vaccines; Immune Response

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We use anatomical and physiological techniques to study synaptic transmission in the cochlea and brain stem in the context of auditory sensory processing and noise-induced hearing loss. Projects include development of therapies to prevent excitotoxicity by antagonizing calcium-permeable AMPA-type glutamate receptors.

Research keywords: Hearing; Synaptic transmission; Drug development

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We are interested in understanding mechanisms underlying how visceral organ function is regulated in the brain and how it influences emotional wellbeing. We utilize scRNAseq, molecular and neuroanatomical tools to obtain comprehensive understanding of how the brain interprets, adapts, and responds to signals from the peripheral organs during normal and pathological states and how it shapes our emotions. We are also fostering new collaborations to developing novel optical and genetic tools for high-throughput sequencing brain nuclei.

Research keywords: pain; single cell genomics; Electrophysiology, in vivo calcium imaging

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Research in my lab is focused on the molecular mechanisms involved in sperm fertility capacity. We are interested in understanding the causes of male unexplained infertility.
Other line of research involve the development of non hormonal female and male contraceptives.

Research keywords: sperm physiology; male fertility; contraception

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The Neuroskeletal Biology Laboratory (NSBL, Scheller Lab) was founded in 2016 and is part of the Musculoskeletal Research Center (MRC) and Division of Bone and Mineral Diseases at Washington University. The laboratory consists of a mix of technicians, graduate students, postdoctoral trainees, clinical fellows and undergraduate researchers. Our laboratory applies concepts from cell biology, physiology, and bioengineering to the study of neurometabolism and neuroskeletal biology. We use rodent models, advanced imaging tools, molecular biology, behavioral assays, etc. Our basic research models are aligned with our clinical studies in the areas of diabetes, metabolism, and bone health.

Research keywords: Neurometabolism; Bone biology; Imaging

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The Schuettpelz lab studies how inflammation regulates hematopoietic stem cells (HSCs) and contributes to the development of hematopoietic malignancies. Inflammatory signals are important for the normal development of the immune system and the response to acute infection or injury, however sustained inflammatory signaling can impair HSC function. Furthermore, inflammatory signals can promote the clonal expansion of mutant HSCs and the development of hematopoietic malignancies. Understanding how both normal and mutant HSCs respond to inflammation is important for identifying strategies to optimize HSCs function and prevent blood cancers.

Research keywords: stem cells; inflammation; cancer

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As a curiosity-driven cancer biology lab, we are interested in dissecting the mechanisms of novel cancer targets with the overarching goal of improving patient outcome. Currently, a major research theme of the lab is genome integrity maintenance with specific focus on two multi-functional proteins, actin-binding factor Profilin-1 and AAA+ ATPase p97/VCP. Our recent work uncovered novel functions of nuclear Profilin-1 and p97/VCP in DNA replication fork dynamics and stability, transcriptional control, and cell cycle checkpoint. It is our ultimate goal to leverage mechanistic insights from such studies to unveil or create “Achilles heels” of cancer cells for more effective treatments.

Research keywords: cancer biology; genome integrity maintenance; chemotherapy resistance

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TIRs is reaching out to prospective graduate students in Chemistry, Biochemistry and Neurosciences. This T32 training program provides a unique opportunity for recently graduated students interested in transitioning their careers into applied molecular imaging focused on design, preclinical validation, development, and translation of PET molecular imaging agents for diagnostic clinical nuclear medicine for application in neurodegenerative diseases (ADRDs).

Research keywords: PET; Probe-Development; Translational-Imaging

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The Shaw laboratory uses the genetic model organism Drosophila melanogaster to elucidate the molecular mechanisms linking sleep to neuronal plasticity. The lab has demonstrated that we can fully restore cognitive functioning to a diverse set of classic memory mutants simply by enhancing their sleep. In these experiments, sleep was able to reverse cognitive deficits without restoring the causal molecular lesion or structural defect. In addition sleep reversed cognitive deficits in two separate models of Alzheimer’s disease.

Research keywords: Sleep; plasticity; circadian

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Hair cells are the exquisitely sensitive sensory receptors of the auditory and vestibular systems. Research in the Sheets Lab focuses on understanding mechanisms of damage to hair-cell organs exposed to noise or ototoxic drugs and discovering cellular processes that drive repair following damage. We use the zebrafish model for our research. Zebrafish lateral-line organs contain hair cells on the surface of the body that are analogous to human hair cells yet are easily accessible. Additionally, we take advantage of the zebrafish’s ability to regenerate complex tissues to identify novel strategies for restoring damaged hair cells and innervating nerves in humans.

Research keywords: sensory neuroscience; regeneration; zebrafish

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We investigate adaptations for intracellular parasitism, focusing on the protozoan parasites Toxoplasma gondii and Cryptosporidium parvum. We currently employ a variety of genetic, biochemical and cellular approaches to address important biological questions. Our studies have revealed the importance innate immunity mechanisms in controlling infection and in parasite virulence factors that thwart innate defenses. We also have several translational projects aims at developing small molecule inhibitors to treat infect and these studies involve high throughput screening, structural biology. and medicinal chemistry.

Research keywords: microbiology; molecular biology; pathogenesis

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My work is at the intersection of medical image analysis, machine learning, and computational neuroscience. I focus on developing novel computational methods to extract information from imaging data and delineate patterns in large heterogeneous data sets, towards improving patient-specific diagnosis and advancing our understanding of brain structure and function in health and disease. Current applications include aging and Alzheimer’s Disease, as well as development and neuropsychiatric disorders

Research keywords: Machine Learning; Medical Image Analysis; Neuroimaging

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We aim to understand how age-related changes in the tumor microenvironment impact tumorigenesis. We’ve shown that aged stromal cells, similar to cancer associated fibroblasts, express p38MAPK/MK2-dependent pro-tumorigenic factors and we’ve developed murine models to explore the role senescent stromal cells play in the preneoplastic and premetastatic niches. Through this work we’ve focused on how inhibition of the p38/MK2 pathway can make metastatic disease susceptible to immunotherapy. More recently, we’ve begun to explore how some of these same changes contribute to therapy-induced comorbidities. The laboratory also examines how age-related changes in the premetastatic niche facilitate tumor cell seeding, dormancy and outgrowth.

Research keywords: senescence; breast cancer; metastasis

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The Stitziel Lab studies mechanisms underlying cardiovascular disease. We use genetic approaches to identify genes and pathways associated with human disease and then employ animal and cellular models to demonstrate causality and understand mechanisms.
Current work includes:
1) SVEP1 which we a) discovered as a novel extracellular matrix protein that causally promotes cardiometabolic disease in humans (Jung et al, Sci Trans Med, 2021) and b) discovered its receptor PEAR1 (Elenbaas et al, Nature Comm 2023).
2) ANGPTL3 which we discovered as a novel regulator of intracellular lipoprotein assembly (Burks et al, under review)
3) Ongoing gene mapping studies

Research keywords: Vascular biology; Lipoprotein metabolism; Human genetics

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Our lab focuses on theoretical and computational neuroscience. We investigate the fundamental physical principles that underlie brain function, from sensing the environment to forming memories and making decisions.

Research keywords: theoretical neuroscience, statistical physics; optimal coding, memory; decision making

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Our research focuses on how immune cells integrate multiple signals to maintain homeostasis within their resident tissues. In many cases, this molecular dialogue is initiated by epithelial cells and innate lymphoid cells (ILCs), which produce hallmark cytokines that reflect subsequent adaptive immune responses mediated by T cells. We are interested in how ILC- and T cell-derived cytokines amplify normal tissue functions to maintain organ health. We employ cutting-edge technical approaches to decode the specific signals that organize these loops in development, tissue injury, and infection to determine whether they can be manipulated to regulate barrier integrity and organ health.

Research keywords: Type 2 immunity; Cytokines; Mucosal immunology

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We are intrigued with the conundrum that while DNA replication and repair are essential for viability, cancer cells with defects in these pathways evolve mechanisms to ensure rapid proliferation. Unravelling this mystery offers possibilities to understand mechanisms that lead to genomic instability and identify vulnerabilities that can catalyze the development of improved therapeutic regimens. Ongoing projects in the lab includes:

• Improve chemotherapeutic responses in BRCA-mutant cancers
• Elucidate the etiology of oncogene-high ovarian cancers
• Deciphering the mechanistic basis of mutational signatures in cancer genomes
Key approaches: Several functional genomic approaches including CRISPR genetic screens and cell biology

Research keywords: DNA repair and replication; Ovarian and Breast Cancer; Oncogene and Tumor Suppressor

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Our laboratory studies the molecular mechanisms that control blood cancer development, with a focus on myelodysplastic syndromes (MDS). MDS results from somatic mutations in hematopoietic cells that clonally evolve over time leading to disease progression. Mutations in genes that regulate RNA splicing occur in 50% of MDS patients, and ongoing work in the lab is uncovering downstream splicing targets that drive early disease pathogenesis. Our program uses primary patient samples to decipher the clonal evolution of tumor cells in serial samples using whole genome and single cell sequencing platforms, and we generate preclinical mouse models for mechanistic and therapeutic studies.

Research keywords: functional genomics; tumor biology; hematopoiesis

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Our laboratory focuses on examining pathogenic events responsible for initiating the development of tissue-specific autoimmune diseases. We aim to dissect key factors involved in type 1 diabetes, an autoimmune disorder that destroys insulin-producing β-cells in the pancreatic islets. The research projects center on 1) Identifying antigenic targets involved in disease pathogenesis using immunopeptidomics to isolate and identify peptide epitopes presented by autoimmune-predisposing MHC molecules; 2) Studying the key features of antigen-specific T cells using single-cell transcriptomics and epigenetic approaches in mice and humans; 3) Examining tissue-resident macrophages that play a critical role in shaping the incoming autoimmune responses.

Research keywords: Autoimmunity; Antigen discovery and presentation; Antigen-specific T cells and tissue-resident macrophages

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My lab focuses on the human microbiome (airway and gut) and lung diseases, specifically asthma. We utilized population-based study, and molecular biology to understand how the climate change alters the human microbiome and the role of microbiome in mediating disease development.

Research keywords: microbiome; climate change; asthma

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We are focused on uncovering mechanisms that lead to restraint of tumor-specific T-cell responses in lung cancer.

Research keywords: neoantigens; tumor immunology; lung cancer

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The Wexler group is focused on theoretical materials innovation for renewable energy and environmental applications, with a special emphasis on developing computational methods for the more realistic modeling of interfacial phenomena in electrocatalysis, solar energy conversion, and environmental energy harvesting. I am driven by the prospects of using first-principles calculations, molecular dynamics and Monte Carlo simulations, and machine learning as a synergistic approach for developing a fundamental understanding of complex materials systems, discovering relationships between their structure and function, and identifying promising routes for device optimization.

Research keywords: Computational chemistry; Theoretical chemistry; Materials chemistry

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