Ben Major, PhD

Professor, Cell Biology & Physiology

We use mass spectrometry-based proteomics to study signal transduction in disease, with a focus on the NRF2 pathway and ‘dark’ kinases. Ongoing projects include the cryoEM structure of KEAP1/NRF2, cell biology of KEAP1 mutations and biomolecular condensates, and small molecule screens for NRF2 inhibitors, including novel compounds that block one-carbon metabolism. We also study NRF2 in new mouse models of cancer and across clinical tumor biopsies using targeted proteomics. We lead a new clinical trial for a NRF2 inhibitor in head and neck cancer. Understudied kinases are being illuminated through large scale promiscuous biotin proximity proteomics and computational scoring.

Research keywords: proteomics; cancer; signal transduction

Basic information

Mentoring statement:Find it here.
Some former postdocs’ career outcomes:Chase Weidmann….assist professor at U of Michigan
Dennis Goldfarb…..assist professor at WashU
Travis Schrank….assist professor at UNC-Chapel Hill
Kathleen Mulvaney… assist professor at Virginia Tech
Feng Yan…….director at IMMORNA
Matt Walker….senior principle scientist at Element Genomics

Postdoc openings within the next year

Number of postdoc positions:1
Postdoc eligibility:U.S. Citizens or Permanent Residents
Current Visa-Holding Trainees in the U.S.
International Trainees Outside the U.S.