David Chen, MD, PhD

Assistant Professor, Medicine

Skin has a remarkable ability to tolerate genetic mutations while remaining clinically cancer-free. This suggests that non-mutational factors may influence the capacity for cells to undergo oncogenic transformation. We conduct studies to understand the interaction between aging, epigenetics, and skin cancer with novel, genetic mouse models of cutaneous squamous cell carcinoma and a robust skin cancer biospecimen bank. We also conduct translational studies to identify melanocyte transition states, and determinants of therapeutic response in metastatic melanoma. We utilize state-of-the art technologies including single-cell RNA-sequencing and epigenomics, as well as mechanism studies via mouse modeling, cell culture, and biochemistry.

Research keywords: Melanoma; Squamous cell carcinoma; premalignancy

Basic information

Mentoring statement:Find it here.
Some former postdocs’ career outcomes:Not provided.

Postdoc openings within the next year

Number of postdoc positions:1
Postdoc eligibility:U.S. Citizens or Permanent Residents
Current Visa-Holding Trainees in the U.S.