Jieya Shao, PhD

Associate Professor, Internal Medicine

As a curiosity-driven cancer biology lab, we are interested in dissecting the mechanisms of novel cancer targets with the overarching goal of improving patient outcome. Currently, a major research theme of the lab is genome integrity maintenance with specific focus on two multi-functional proteins, actin-binding factor Profilin-1 and AAA+ ATPase p97/VCP. Our recent work uncovered novel functions of nuclear Profilin-1 and p97/VCP in DNA replication fork dynamics and stability, transcriptional control, and cell cycle checkpoint. It is our ultimate goal to leverage mechanistic insights from such studies to unveil or create “Achilles heels” of cancer cells for more effective treatments.

Research keywords: cancer biology; genome integrity maintenance; chemotherapy resistance

Basic information

Mentoring statement:Not provided.
Some former postdocs’ career outcomes:I have trained five postdocs so far. One is currently in training. Two have found industry jobs in the US. The other two secured faculty jobs and are currently working as Assistant Professors in China and Japan.

Postdoc openings within the next year

Number of postdoc positions:2
Postdoc eligibility:U.S. Citizens or Permanent Residents
Current Visa-Holding Trainees in the U.S.
International Trainees Outside the U.S.