We focus on mechanisms of CD8 T cell activation in the central nervous system (CNS), and their implications in neurodegeneration and cancer. By studying the neurodegenerative disease Amyotrophic Lateral Sclerosis 4 (ALS4), caused by a mutation in the gene SETX, we found that CD8 T cells of likely autoimmune origin are activated in the CNS and blood of patients and mice, and correlate with disease progression and resistance to glioma in mice. We want to explore: The role of CD8 T cells in the pathogenesis of ALS, in humans and mice; The role of SETX in T cell activation.
Research keywords: Immunology/T cells; Neurodegeneration; Cancer
Basic information
| Pronouns: | She/Her/Hers |
| Mentoring statement: | Not provided. |
| Some former postdocs’ career outcomes: | Not provided, |
| Other info: | https://hopecenter.wustl.edu/people/laura-campisi-phd/ |
Postdoc openings within the next year
| Number of postdoc positions: | 2 |
| Postdoc eligibility: | U.S. Citizens or Permanent Residents Current Visa-Holding Trainees in the U.S. International Trainees Outside the U.S. |