Our laboratory studies the molecular mechanisms that control blood cancer development, with a focus on myelodysplastic syndromes (MDS). MDS results from somatic mutations in hematopoietic cells that clonally evolve over time leading to disease progression. Mutations in genes that regulate RNA splicing occur in 50% of MDS patients, and ongoing work in the lab is uncovering downstream splicing targets that drive early disease pathogenesis. Our program uses primary patient samples to decipher the clonal evolution of tumor cells in serial samples using whole genome and single cell sequencing platforms, and we generate preclinical mouse models for mechanistic and therapeutic studies.
Research keywords: functional genomics; tumor biology; hematopoiesis
Basic information
| Pronouns: | He/Him/His |
| Mentoring statement: | Find it here. |
| Some former postdocs’ career outcomes: | Academic center: Full Professor (1), Associate Professor (2), Assistant Professor (3), Industry (2), Medical School (1) |
Postdoc openings within the next year
| Number of postdoc positions: | 1 |
| Postdoc eligibility: | U.S. Citizens or Permanent Residents Current Visa-Holding Trainees in the U.S. |