Peggy Kendall, MD

Professor and Chief, Medicine (Allergy & Immunology)

The Kendall Lab studies B lymphocyte contributions to autoimmune and allergic diseases including Type 1 diabetes, rheumatoid arthritis and food allergy. We discovered that B lymphocyte signaling through Bruton’s tyrosine kinase (BTK) governs development of autoreactive cells. Targeting BTK eliminates autoreactive, but not normal cells, making it an attractive therapeutic option for fighting autoimmune disease without causing immunodeficency. We also work with nanoparticle therapeutics. Finally, we have discovered that B lymphocyte signaling is important for proper IgA development, leading to extensive studies of mucosal immunity including gut health, IgA sequences and specificity, and microbiome in relationship to autoimmune disease.

Research keywords: B lymphocytes; Autoimmune disease; Microbiome

Basic information

Mentoring statement:Not provided.
Some former postdocs’ career outcomes:Post-doctoral trainees in my lab have gone onto the following positions:
1. Industry position
2. Started own small biotech company
3. Tenure Track Assistant Professors
4. Employed at the CDC
5. Transitioning to Research Faculty positions

Skill sets and knowledge post-docs in the Kendall lab obtain include:
A. High-dimensional unbiased CyTOF analysis of peripheral blood from patient
B. Antibody sequencing and analysis
C. Microbiome sequencing and analysis
D. Disease models for T1D and RA.
E. Immunology of autoimmune disease
F. In vitro assays for Lymphocyte function, cell signaling and other immune-related assays.
G. Immunofluorescent and other microscopy of murine and human tissues.
H. Two photon in vitro microscopy.
I. Nanoparticle therapeutic preclinical testing

Postdoc openings within the next year

Number of postdoc positions:3+
Postdoc eligibility:U.S. Citizens or Permanent Residents
Current Visa-Holding Trainees in the U.S.