My lab focuses broadly on the leukocyte migration (or trafficking) in the setting of tumor immunology. We have been working on a novel leukocyte chemoattractant protein, chemerin. Our ongoing work will continue to further define the mechanisms by which chemerin mediates its anti-tumor effect, and ultimately we hope to translate this into a first in class immunotherapeutic that could augment leukocyte trafficking to sites of tumor in humans. We have recently received a patent for our tumor targeted immunotherapy and are translating this into the clinic and will work on the first in human clinical trial. As a Physician-Scientist who sees and treats patients with genitourinary malignancies, I have been able to establish a robust human tissue bank and thus another focus in the lab is on translational studies of human prostate cancer tissues using advances multi-omic methods such as single cell RNAseq and multiplexed imaging modalities.
Research keywords: tumor immunology; prostate cancer; leukocyte trafficking
Basic information
| Pronouns: | He/Him/His |
| Mentoring statement: | Not provided. |
| Some former postdocs’ career outcomes: | Not provided. |
| Other info: | https://sites.wustl.edu/pachynskilab/research/ |
Postdoc openings within the next year
| Number of postdoc positions: | 2 |
| Postdoc eligibility: | U.S. Citizens or Permanent Residents Current Visa-Holding Trainees in the U.S. International Trainees Outside the U.S. |