Associate Professor, Biochemistry & Molecular Biophysics
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The Mayo Clinic has published a DNA 20mer (selected in vitro to bind myelin) that apparently leads to remyelinization and recovery in a mouse M.S. model. But it only works as a complex with 4 streptavidins, I.P. 3x per week, and is expected to be immunogenic. I have selected [SELEX] non-immunogenic 95mer nucleic acids that reach the brain from intravenous tail vein injections. These could replace the streptavidins, and were selected to carry a cargo of 45mer. Only 4h timepoint so far. Exciting idea for long lifetime.
Research keywords: multiple sclerosis; aptamers; DNA technology