Biochemistry & Molecular Biophysics
Wayne Barnes, PhD
Associate Professor, Biochemistry & Molecular Biophysics
- Email: barneswm@wustl.edu
The Mayo Clinic has published a DNA 20mer (selected in vitro to bind myelin) that apparently leads to remyelinization and recovery in a mouse M.S. model. But it only works as a complex with 4 streptavidins, I.P. 3x per week, and is expected to be immunogenic. I have selected [SELEX] non-immunogenic 95mer nucleic acids that reach the brain from intravenous tail vein injections. These could replace the streptavidins, and were selected to carry a cargo of 45mer. Only 4h timepoint so far. Exciting idea for long lifetime.
Research keywords: multiple sclerosis; aptamers; DNA technology
Ben Garcia, PhD
Professor and Chair, Biochemistry & Molecular Biophysics
- Email: bagarcia@wustl.edu
Quantitative proteomics for understanding protein and proteome modifications.
Research keywords: Mass Spectrometry