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Melissa Mavers, MD, PhD

Assistant Professor, Pediatrics (Hematology and Oncology)

Work in our lab focuses on immune regulation of graft-versus-host disease (GVHD), a debilitating and potentially fatal complication of hematopoietic stem cell transplantation (HSCT). HSCT can cure high-risk malignancies and other blood and bone marrow diseases, yet success is limited by this devastating complication.
We aim to elucidate the biological mechanisms underlying immune tolerance in HSCT and develop approaches to enhance regulatory immune cells for GVHD prevention and treatment. Our goal is to develop a cellular therapy for GVHD with a bench-to-bedside approach, engineering viable advances for prevention and cure, and making HSCT a safer way to cure hematologic diseases.

Research keywords: T cells; cellular therapy; immune regulation

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