Rheumatology

The Kefalogianni lab studies the cellular and molecular mechanism of tissue injury and disease progression. Various pathologies are associated with tissue injury, including hypoxia, diabetes, infections, and autoimmune diseases. While mechanisms to repair the damaged tissues get activated, severe or repeated injury can drive non-resolving inflammation, tissue scarring (fibrosis), and progression to chronic disease conditions that may lead to organ function loss. Systemic effects, such as remote organ injuries are also common. Our current projects focus on the roles of cytokines and their cellular and soluble receptors in the progression of rheumatic and kidney diseases.

Research keywords: cell signaling; TNF; fibrosis

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