Surgery
Su-Hsin Chang, PhD
Associate Professor, Surgery
- Email: chang.su-hsin@wustl.edu
My research is focused on health and economic burden of obesity and obesity-related multimorbidity, multiple myeloma prevention and control, surgical treatment for obesity, transplant outcomes, and health disparities.
Research keywords: Obesity; Cancer; Disparities
Aimee James, PhD
Professor, Surgery (Public Health Sciences)
- Email: aimeejames@wustl.edu
Our T32 postdoc program is focused on transdisciplinary cancer prevention and control research. Faculty study health equity, disparities, engagement, and the full continuum from prevention through survivorship. Our program includes postdocs from diverse backgrounds and a range of disciplines including, but not limited to, epidemiology, psychology, community health, public health, social work, implementation science, and other related fields. My own research is focused on improve equity and outcomes in cancer screening and early detection, using community engaged research in low resource settings.
Research keywords: cancer control; cancer prevention; health equity
Jae-Sung Kim, PhD
Professor, Surgery and Cell Biology & Physiology
- Email: kjaesung@wustl.edu
We investigate the mechanisms of non-alcoholic fatty liver disease (NAFLD) with a focus on mitochondria and autophagy. We also seek to develop new therapeutic strategies to reduce hepatic injury after liver resection and transplant of fatty livers. Our study models include mice, rats, and human livers. Our study has potentials to 1) develop therapeutic strategies to reduce fatty liver disease and 2) expand donor liver pool. Currently, fatty donor livers are discarded without transplant.
Research keywords: liver; mitochondria; autophagy
Nupam Mahajan, PhD
Endowed Professor, Surgery
- Email: nupam@wustl.edu
The lab theme is to determine how tyrosine kinases, phosphatases, demethylases and nuclear receptors regulates epigenetic processes that affect cellular homeostasis, immune impairment and cancer cell survival.
Current Projects in Lab
Epigenetic signaling in dampening immune response to tumors
Characterization of new subsets of T cells and neutrophils
Androgen regulated immune response
Characterization of KDM6 inhibitors
New `dual’ therapeutic molecules
Major findings of our lab include:
Discovered 5 new epigenetic events:
Identified a novel lncRNA, NXTAR
Developed inhibitor for ACK1, (R)-9b
Identified AKT Tyr176-phosphorylation
Identified AR Lys609-acetylation
Identified a new class of KDM6 inhibitor
Research keywords: Breast & Prostate Cancer; Immune regulation; Epigenetics