Xiaoxiao Wan, MD, PhD

Assistant Professor, Pathology & Immunology

Our laboratory focuses on examining pathogenic events responsible for initiating the development of tissue-specific autoimmune diseases. We aim to dissect key factors involved in type 1 diabetes, an autoimmune disorder that destroys insulin-producing β-cells in the pancreatic islets. The research projects center on 1) Identifying antigenic targets involved in disease pathogenesis using immunopeptidomics to isolate and identify peptide epitopes presented by autoimmune-predisposing MHC molecules; 2) Studying the key features of antigen-specific T cells using single-cell transcriptomics and epigenetic approaches in mice and humans; 3) Examining tissue-resident macrophages that play a critical role in shaping the incoming autoimmune responses.

Research keywords: Autoimmunity; Antigen discovery and presentation; Antigen-specific T cells and tissue-resident macrophages

Basic information

Mentoring statement:Find it here.
Some former postdocs’ career outcomes:Not provided.

Postdoc openings within the next year

Number of postdoc positions:2
Postdoc eligibility:U.S. Citizens or Permanent Residents
Current Visa-Holding Trainees in the U.S.
International Trainees Outside the U.S.